3-(4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-2-propenoic acid, artepillin C
| Name | Artepillin C | ||
| PubChem CID | 5472440 | ||
| Molecular Weight | 300.4g/mol | ||
| Synonyms |
3-(4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-2-propenoic acid, artepillin C |
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| Formula | C₁₉H₂₄O₃ | ||
| SMILES | CC(=CCC1=CC(=CC(=C1O)CC=C(C)C)C=CC(=O)O)C | ||
| InChI | 1S/C19H24O3/c1-13(2)5-8-16-11-15(7-10-18(20)21)12-17(19(16)22)9-6-14(3)4/h5-7,10-12,22H,8-9H2,1-4H3,(H,20,21)/b10-7+ | ||
| InChIKey | KABCFARPAMSXCC-JXMROGBWSA-N | ||
| CAS Number | 72944-19-5 | ||
| ChEMBL ID | CHEMBL456309 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | KuShen | ||
| Use Part | Root | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Liver, Stomach, Large intestine, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora flavescens
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| Chineses Pinyin | YinChen | ||
| Use Part | Whole Herb | ||
| Habitat | China | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Spleen, Stomach, Liver, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Artemisia
-->Species: Artemisia scoparia
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| Chineses Pinyin | YinChenHao | ||
| Use Part | Aerial Parts | ||
| Habitat | LiaoNing, HeBei, Shaanxi, ShanDong, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, TaiWan, HeNan, HuBei, HuNan, GuangDong, GuangXi, SiChuan | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Liver, Spleen, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Artemisia
-->Species: Artemisia capillaris
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| Chineses Pinyin | BaXiLvFengJiao | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Magnoliopsida
-->Order: Brassicales
-->Family: Moringaceae
-->Genus: Propolis
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| Pair Name | Artepillin C, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | NFKB1 | hsa4790 |
| Up-regulation | Activity | RELA | hsa5970 | |
| In Vitro Model | LNCaP | Prostate carcinoma | Homo sapiens (Human) | CVCL_0395 |
| Result | The data demonstrate the important role of Brazilian green propolis and its bioactive compounds in prostate cancer chemoprevention through the enhancement of TRAIL-mediated apoptosis. | |||
